EEG 第７回定例会

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　NEWS(5/17更新） *************************Events&conferences (5/16更新）

・Exosome-delivered microRNAs of "chromosome 19 microRNA cluster" as immunomodulators in pregnancy and tumorigenesis.

・Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands.

・Spatial partitioning of the regulatory landscape of the X-inactivation centre

・Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution.

・De novo mutations revealed by whole-exome sequencing are strongly associated with autism.

・Nitric oxide modifies chromatin to suppress ICAM-1 expression during colonic inflammation.

・Behavioral plasticity in honey bees is associated with differences in brain microRNA transcriptome.

・Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver.

・Age-associated DNA methylation in pediatric populations.

・Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset.

・Age-associated DNA methylation in pediatric populations.

・Lysine Methyltransferase G9a is Not Required for DNMT3A/3B Anchoring to Methylated Nucleosomes and Maintenance of DNA Methylation in Somatic Cells.

・Common Variants in 6 Lipid-Related Genes Discovered by High-Resolution DNA Melting Analysis and Their Association with Plasma Lipids・Assisted reproduction treatment and epigenetic inheritance.

・5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.

・Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity.Dramatic replacement of histone variants during genome remodeling in nuclear-transferred embryos・Methylation of O (6)-methylguanine-DNA methyltransferase (MGMT) promoter gene in triple-negative breast cancer patients.

・Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.

・Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains.

・Enhancer-driven chromatin interactions during development promote escape from silencing by a long non-coding RNA

・Associations with early-life socio-economic position in adult DNA methylation

・Non-invasive prenatal diagnosis of trisomy 21 by dosage ratio of fetal chromosome-specific epigenetic markers in maternal plasma.

・Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.

・Identification of Four Potential EpigeneticModulators from the NCI Structural Diversity Library Using a Cell-Based Assay

Anne M. Best,1 Jianjun Chang,1 Angie B. Dull,2 John A. Beutler,3 and Elisabeth D.Martinez1,1Department of Pharmacology and Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center,6000 Harry Hines Boulevard, Dallas, TX 75390, USA,2Molecular Targets Laboratory, Center for SAIC-Frederick, National Cancer Institute, Frederick, MD 21702, USA3Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Boulevard, Dallas, TX 75390, USA
Correspondence should be addressed to Elisabeth D. Martinez, Receivedelisabeth.martinez@utsouthwestern.edu 29 July 2010; Accepted 7 October 2010
Academic Editor: Minoru YoshidaCopyright ? 2011 Anne M. Best et al.

This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Epigenetic pathways help control the expression of genes. In cancer and other diseases, aberrant silencing or overexpression of　genes, such as those that control cell growth, can greatly contribute to pathogenesis. Access to these genes by the transcriptional　machinery is largely mediated by chemical modifications of DNA or histones, which are controlled by epigenetic enzymes,making these enzymes attractive targets for drug discovery. Here we describe the characterization of a locus derepression assay,
a fluorescence-based mammalian cellular system which was used to screen the NCI structural diversity library for novel epigenetic　modulators using an automated imaging platform. Four structurally unique compounds were uncovered that, when furtherinvestigated, showed distinct activities. These compounds block the viability of lung cancer and melanoma cells, prevent cell　cycle progression, and/or inhibit histone deacetylase activity, altering levels of cellular histone acetylation.

・Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.

・Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.

・Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine.

・A Comprehensive Survey of miRNA Repertoire and 3' Addition Events in the Placentas of Patients with Pre-Eclampsia from High-Throughput Sequencing.

・Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans

Volume 6, Issue 9 September 2011

・Increased methylation variation in epigenetic domains across cancer types.

・Mechanism for stress-induced epigenetic inheritance uncovered in new study

・Tissue specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genome.

・Primate CpG islands are 　maintained by heterogeneous evolutionary regimes involving minimal 　selection.

・SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder.

・Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase.

・Non-coding RNAs as regulators of gene expression and epigenetics.

・Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.

・Epigenetic modulation of the renal β-adrenergic?WNK4 pathway in salt-sensitive hypertension

・Lysine Methyltransferase G9a is Not Required for DNMT3A/3B Anchoring to Methylated Nucleosomes and Maintenance of DNA Methylation in Somatic Cells.

・Common Variants in 6 Lipid-Related Genes Discovered by High-Resolution DNA Melting Analysis and Their Association with Plasma Lipids・Assisted reproduction treatment and epigenetic inheritance.

・5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.

・2nd Max Planck Freiburg Epigenetics Meeting

Max Planck

Location: Berlin, Germany
Date: December 5, 2012Conference Website
Organizers: Asifa Akhtar, Thomas Jenuwein

・Genomics Research Asia 2012

Select Biosciences

Location: Daejon, South Korea
Date: November 13, 2012Conference Website
Organizers: Aaron Woodley

・Epigenetics & Chromatin

CSHL Meetings

Location: Cold Spring Harbor, NY
Date: September 11, 2012Conference Website
Organizers: Shelley Berger, Robert Kingston, Juerg Mueller

・Environmental Mutagen Society Meeting 2012

Date:09/08/2012

・Epigenetics 2012

・ISSCR Annual Meeting 2012

Location: Yokohama, Japan
Date: June 13, 2012Conference Website
Organizers: International Society for Stem Cell Research

Australian Scientific Conference

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環境エピゲノミクス研究会（Environmental epigenomics society:EEG研究会）会則　：　入会申し込み　　　　一般・学生会員　　　賛助会員

Environmental Epigenomics（環境ゲノム発現撹乱）” への招待

澁谷　徹　(“Tox21” 研究所)　　（t.shibuya.tox21@zpost.plala.or.jp）

最近，”Epigenetics”という言葉を種々のメディアでよく目にする．遺伝子DNAは，配偶子形成段階および個体の発生中，あるいは定常状態にある成体の分裂細胞において，正確にその遺伝情報を複製するとともに，その遺伝情報を時間的および空間的に正確に発現して，個体の発生過程および成体の生命機能を維持している．この遺伝子発現の統御機構を”Epigenetics”という(1)．当然、発生中の胎児細胞においては,成体に比べてより高度な制御をうけている．日本語ではよい訳語がないので,英語そのままに「エピジェネテックス」と呼ばれている．現在，大きな注目を浴びているiPS細胞は，”Epigenetics”を自由に操作することで再生医学に応用出来ることが期待されている細胞である．

Figure 1. Waddington’s Classical Epigenetic Landscape
In 1957, Conrad Waddington proposed the concept of an epigenetic
landscape to represent the process of cellular decision-making during
development. At various points in this dynamic visual metaphor,
the cell (represented by a ball) can take specific permitted trajectories,
leading to different outcomes or cell fates. Figure reprinted from
Waddington, 1957. (Cell 128, February 23, 2007)

Epigenomic-Developmental- Toxicology の提唱 　　　　　　

　澁谷　徹・堀谷幸治　（“Tox21”研究会）　　　t.shibuya.tox21@zpost.plala.or.jp

　“Toxicology”（毒性学）は総合的な応用生命科学である．その目的は，最新の科学知識・技術を駆使して，新規あるいは既存の化学物質，薬品および食品などのヒトへの毒性を予測し，それらのリスクを回避あるいは軽減させることである．ヒトは他の生物種とは異なり，その優れた頭脳をもって，多くの化学物質を開発し，その利便性を得てきた．しかし，ヒトもまた生物であるので，これらの化学物質による毒性によって，種々の有害作用を受けてきた例がこれまでも多く認められている．これらの化学物質から，38億年にわたる生命の進化の過程を経て創生された生物であるヒトの健康を，現在あるいは将来にわたって保全することは毒性学の重要な任務である (1)．“Toxicology” の概念や技術は，科学の進歩に伴って改革されることは当然である．近年の「遺伝子の構造と発現」をめぐる著しい研究の進歩は，毒性学に根源的な変革を迫っている．

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賛助会員コーナー　　　Tox21　　 イーエス・サポート

戦略的創造研究推進事業（CREST）「エピゲノム研究に基づく診断・治療へ向けた新技術の創出」の公募のお知らせ

http://www.jst.go.jp/kisoken/crest/ryoiki/bunyah23-4.html